Nerve-cancer cell cross-talk: a novel promoter of tumor progression

Title: Nerve-cancer cell cross-talk: a novel promoter of tumor progression
Creator: Jobling, Phillip; Pundavela, Jay; Oliveira, Sonia M. R.; Roselli, Séverine; Walker, Marjorie M.; Hondermarck, Hubert
Relation: Cancer Research Vol. 75, Issue 9, p. 1777-1781
Publisher Link: http://dx.doi.org/10.1158/0008-5472.CAN-14-3180
Publisher: American Association for Cancer Research
Resource Type: journal article
Date: 2015
Description: Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells.
Subject: nerves; tumor progression; cancer cell growth
Identifier: http://hdl.handle.net/1959.13/1342216
Identifier: uon:28919
Identifier: ISSN:0008-5472
Language: eng
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